Site ftsH
- Name: ftsH
- Type: Gene
- Synonyms
b3178 MG1655 locus tag hflB Banuett et al., original discovery as high freq. lysogeny mrsC mrsC505 affects mRNA stability tolZ Col resistance - Mnemonic: filamentation temperature sensitivity
- Left End Point: 71.62
- Right End Point: 71.66
- Products:
cytoplasmic membrane protein FtsH, an ATP-dependent protease - Direction: <
- Properties:
Property Comment encodes membrane protein NULL essential gene septum formation - Priority: 1
- 2 Alleles of This Gene
ftsH0 ftsH792-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank M83138 EcoGene.org EG11506 EcoliWiki ftsH - Comment:
- Lysogeny\&level of lambda cII protein.TolZ. Encodes member of novel putative ATPase family functioning in prot.transport,cell div cycle,etc. Essential f.septum formation.ATP-dep.protease acts on SecY
- References:
- Banuett, F., M.A. Hoyt, L. McFarlane, H. Echols, I. Herskowitz 1986. hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein. J.Mol.Biol. 187:213-224
- Tomoyasu, T., T. Yuki, S. Morimura, H. Mori, K. Yamanaka, H. Niki, S. Hiraga, T. Ogura 1993. The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene
- Herman, C., T. Ogura, T. Tomoyasu, S. Hiraga, Y. Akiyama, K. Ito, R. Thomas, R. D'Ari, P. Bouloc 1993. Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB. Proc.Natl.Acad.Sci.USA 90:10861-10865
- Akiyama, Y., Y. Shirai, K. Ito 1994. Involvement of FtsH in protein assembly into and through the membrane. II. Dominant mutations affecting FtsH functions. J.Biol.Chem. 269:5225-5229
- Herman, C., D. Thevenet, R. D'Ari, P. Bouloc 1995. Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB. Proc.Natl.Acad.Sci.USA 92:3516-3520
- Akiyama, Y., A. Kihara, K. Ito 1996. Subunit a of proton ATPase F0 sector is a substrate of the FtsH protease in Escherichia coli. FEBS Lett. 399:26-28
- Qu, J.N., S.I. Makino, H. Adachi, Y. Koyama, Y. Akiyama, K. Ito, T. Tomoyasu, T. Ogura, H. Matsuzawa 1996. The tolZ gene of Escherichia coli is identified as the ftsH gene. J.Bacteriol. 178:3457-3461
- Wang, R.F., E.B. O'Hara, M. Aldea, C.I. Bargmann, H. Gromley 1998. Escherichia coli mrsC is an allele of hflB, encoding a membrane-associated ATPase and protease that is required for mRNA decay. J.Bacteriol. 180:1929-1938
- Granger, L.L., E.B. O'Hara, R.F. Wang, F.V. Meffen, K. Armstrong, S.D. Yancey, P. Babitzke, S.R. Kushner 1998. The Escherichia coli mrsC gene is required for cell growth and mRNA decay. J.Bacteriol. 180:1920-1928
- Inagawa, T., J. Kato, H. Niki, K. Karata, T. Ogura 2001. Defective plasmid partition in ftsH mutants of Escherichia coli. Molecular Genetics & Genomics: MGG 265:755-762