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Site fabI
- Name: fabI
- Type: Gene
- Synonyms
b1288 MG1655 locus tag envM qmeA - Mnemonic: Fatty acid biosynthesis
- Left End Point: 29.06
- Right End Point: 29.08
- Products:
enoyl-ACP reductase, NADH-dependent - Direction: <
- Properties:
Property Comment triclosan resistant allele specific missense allele gives resistance to triclosan, broad spectrum antibiotic inhibiting fatty acid biosynthesis - Priority: 1
- 2 Alleles of This Gene
fabI392(ts) fabI796-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank M97219 EcoGene.org EG11528 EcoliWiki fabI - Comment:
- References:
- Wijsman, H.J.W. 1972. Mutation affecting plasmolysis in Escherichia coli. J.Bacteriol. 110:789-790
- Wijsman, H.J.W., H.C. Pafort 1974. Pleiotropic mutations in Escherichia coli conferring tolerance to glycine and sensitivity to penicillin. Mol.Gen.Genet. 128:349-357
- Turnowsky, F., K. Fuchs, C. Jeschek, G. Hogenauer 1989. envM genes of Salmonella typhimurium and Escherichia coli. J.Bacteriol. 171:6555-6565
- Bergler, H., G. Hogenauer, F. Turnowsky 1992. Sequences of the envM gene and of two mutated alleles in Escherichia coli. J.Gen.Microbiol. 138:2093-2100
- Bergler, H., P. Wallner, A. Ebeling, B. Leitinger, S. Fuchsbichler, H. Aschauer, G. Kollenz, G. Hogenauer, F. Turnowsky 1994. Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli. J.Biol.Chem. 269:5493-5496
- Heath, R.J., C.O. Rock 1995. Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. J.Biol.Chem. 270:26538-26542
- Kleerebezem, M., M. Heutink, H. de Cock, J. Tommassen 1996. The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase. Res.Microbiol. 147:609-613
- Heath, R.J., J.R. Rubin, D.R. Holland, E. Zhang, M.E. Snow, C.O. Rock 1999. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J.Biol.Chem. 274:11110-11114