Site dnaN
- Name: dnaN
- Type: Gene
- Synonyms
b3701 MG1655 locus tag - Mnemonic: DNA
- Left End Point: 83.61
- Right End Point: 83.63
- Products:
DNA polymerase III holoenzyme, beta-subunit beta-clamp processivity factor for DNAP III - Direction: <
- Properties:
Property Comment SOS-related See beta* comment. Modest,slow induction under some DNA damage conditions, requiring recA and lexA for transcriptional induction, but promoter has no LexA box. - Priority: 1
- 2 Alleles of This Gene
dnaN159(ts) dnaN59 - External Database Links:
Host Site Page Links EcoGene.org EG10242 EcoliWiki dnaN - Comment:
- DNA biosynthesis. This subunit is termed the sliding clamp subunit. Required for high processivity. An internal in-frame gene, dnaN* encodes the smallerbeta*, which is UV-inducible, gives UV-resist.
- References:
- Kimura, A., T. Miki, S. Hiraga, T. Nagata, T. Yura 1979. Conditionally lethal amber mutations in the dnaA region of the Escherichia coli chromosome that affect chromosome replication. J.Bacteriol. 140:825-834
- Sakakibara, Y., T. Mizukami 1980. A temperature-sensitive Escherichia coli mutant defective in DNA replication: dnaN, a new gene adjacent to the dnaA gene. Mol.Gen.Genet. 178:541-553
- Yuasa, S., Y. Sakakibara 1980. Identification of dnaA and dnaN gene products of Escherichia coli. Mol.Gen.Genet. 180:267-273
- Ream, L.W., L.J. Margossian, A.J. Clark, F.G. Hansen, K. von Meyenburg 1980. Genetic and physical mapping of recF in Escherichia coli K-12. Mol.Gen.Genet. 180:115-121
- Sako, T., Y. Sakakibara 1980. Coordination expression of Escherichia coli dnaA and dnaN genes. Mol.Gen.Genet. 179:521-526
- Sakakibara, Y., H. Tsukano, T. Sako 1981. Organization and transcription of the dnaA and dnaN genes of Escherichia coli. Gene 13:47-55
- Burgers, P.M.J., A. Kornberg, Y. Sakakibara 1981. The dnaN gene codes for the beta subunit of DNA polymerase III holoenzyme of Escherichia coli. Proc.Natl.Acad.Sci.USA 78:5391-5395
- Hansen, E.B., F.G. Hansen, K. von Meyenburg 1982. The nucleotide sequence of the dnaA gene and the first part of the dnaN gene of Escherichia coli K-12. Nucleic Acids Res. 10:7373-7385
- Ream, L.W., A.J. Clark 1983. Cloning and deletion mapping of the recF dnaN region of the Escherichia coli chromosome. Plasmid 10:101-110
- Ohmori, H., A. Kimura, T. Nagata, Y. Sakakibara 1984. Structural analysis of the dnaA and dnaN genes of Escherichia coli. Gene 28:159-170
- Armengod, M.-E., E. Lambies 1986. Overlapping arrangement of the recF and dnaN operons of Escherichia coli: positive and negative control sequences. Gene 43:183-196
- Quinones, A., W. Messer 1988. Discoordinate gene expression in the dnaA-dnaN operon of Escherichia coli. Mol.Gen.Genet. 213:118-124
- Kelman, Z., M.A. O'Donnell 1995. DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine. Annu.Rev.Biochem. 64:171-200