Site btuB
- Name: btuB
- Type: Gene
- Synonyms
b3966 MG1655 locus tag bfe cer - Mnemonic: B12 uptake
- Left End Point: 89.70
- Right End Point: 89.74
- Products:
receptor for vitamin B12, E colicins, and phage BF23 - Direction: >
- Properties:
Property Comment transport gene B12: unusual specific transport across outer membrane due to size and low conc. - Priority: 1
- 8 Alleles of This Gene
btuB3191::Tn10 btuB3192::Tn10kan btuB451 btuB460::Tn10 btuB501 btuB51 btuB69 btuB754(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M10112 EcoGene.org EG10126 EcoliWiki btuB - Comment:
- Heller et al. JB 161: 896,904. seq. ca. 1840 nucs, .039 min. Selectable. Pheno. Also adsorption of lytic phage C1
- References:
- Buxton, R.S. 1971. Genetic analysis of Escherichia coli K-12 mutants resistant to bacteriophage BF23 and the E-group colicins. Mol.Gen.Genet. 113:154-156
- Kadner, R.J., Liggins 1973. Transport of vitamin B12 in Escherichia coli: genetic studies. J.Bacteriol. 115:514-521
- Moran, M.C., A.J. Mazaitis, R.H. Vogel, A.D. David 1979. Clustered arg genes on a Bam HI segment of the Escherichia coli chromosome. Gene 8:25-34
- Pugsley, A.P. 1985. Escherichia coli K12 strains for use in identification and characterization of colicins. J.Gen.Microbiol. 131:369-376
- Heller, K., R.J. Kadner 1985. Nucleotide sequence of the gene for the vitamin B12 receptor protein in the outer membrane of Escherichia coli. J.Bacteriol. 161:904-908
- Aufrere, R., M. Tempete, J.P. Bohin 1986. Overlapping reading frames in Escherichia coli. The two promoters and the first 65 nucleotides of a gene related to the rrnB operon are localized in the coding sequence of btuB. C.R.Acad.Sci.Ser.III 303:49-54
- Aufrere, R., M. Tempete, J.P. Bohin 1986. Regulation of expression of the gene for vitamin B12 receptor cloned on a multicopy plasmid in Escherichia coli. Mol.Gen.Genet. 205:358-365
- Gudmundsdottir, A., C. Bradbeer, R.J. Kadner 1988. Altered binding and transport of vitamin B12 resulting from insertion mutations in the Escherichia coli btuB gene. J.Biol.Chem. 263:14224-14230
- Gudmundsdottir, A., P.E. Bell, M.D. Lundrigan, C. Bradbeer, R.J. Kadner 1989. Point mutations in a conserved region (TonB box) of Escherichia coli outer membrane protein BtuB affect vitamin B12 transport. J.Bacteriol. 171:6526-6533
- Lathrop, J.T., B.Y. Wei, G.A. Touchie, R.J. Kadner 1995. Sequences of the Escherichia coli BtuB protein essential for its insertion and function in the outer membrane. J.Bacteriol. 177:6810-6819
- Hufton, S.E., R.J. Ward, N.A.C. Bunce, J.T. Armstrong, A.J.P. Fletcher, R.E. Glass 1995. Structure-function analysis of the vitamin B12 receptor of Escherichia coli by means of informational suppression. Mol.Microbiol. 15:381-393
- Likhacheva, N.A., V.V. Samsonov, V.V. Samsonov, S.P. Sineoky 1996. Genetic control of the resistance to phage C1 of Escherichia coli K-12. J.Bacteriol. 178:5309-5315
- Nahvi, A., N. Sudarsan, M.S. Ebert, X. Zou, K.L. Brown, R. Breaker 2002. Genetic control by a metabolite binding mRNA. Chem.Biol. 9:1043-1049