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Site birA
- Name: birA
- Type: Gene
- Synonyms
b3973 MG1655 locus tag bioR dhbB - Mnemonic: Biotin retention
- Left End Point: 89.90
- Right End Point: 89.92
- Products:
biotin-[acetyl-CoA carboxylase] holoenzyme synthetase biotin-protein ligase - Direction: >
- Properties:
Property Comment regulatory gene both a biosyn.enzyme and a repressor autogenously regulated NULL - Priority: 1
- 6 Alleles of This Gene
birA1 birA136 birA207 birA791-YFP(::cat) birA85 birA91 - External Database Links:
Host Site Page Links NCBI/GenBank M10123 EcoGene.org EG10123 EcoliWiki birA - Comment:
- Selectable Phenotype. a-Dehydrobiotin resistance.
- References:
- Pai, C.H. 1974. Biochemical and genetic characterization of dehydrobiotin resistant mutants of Escherichia coli. Mol.Gen.Genet. 134:345-357
- Campbell, A., R. Chang, D. Barker, G. Ketner 1980. Biotin regulatory (bir) mutations of Escherichia coli. J.Bacteriol. 142:1025-1028
- Barker, D.F., A. Campbell 1980. Use of bio-lac fusion strains to study regulation of biotin biosynthesis in Escherichia coli. J.Bacteriol. 143:789-800
- Barker, D.F., A. Campbell 1981. Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin in Escherichia coli. J.Mol.Biol. 146:469-492
- Barker, D.F., A. Campbell 1981. The birA gene of Escherichia coli encodes a biotin holoenzyme synthetase. J.Mol.Biol. 146:451-467
- Howard, P.K., J. Shaw, A.J. Otsuka 1985. The nucleotide sequence of the birA gene encoding the biotin operon repressor and biotin holoenzyme synthetase functions of Escherichia coli. Gene 35:321-331
- Maloy, S.R., V.J. Stewart 1993. Autogenous regulation of gene expression. J.Bacteriol. 175:307-316
- Xu, Y., D. Beckett 1996. Evidence for interdomain interaction in the Escherichia coli repressor of biotin biosynthesis from studies of an N-terminal domain deletion mutant. Biochemistry 35:1783-1792
- Streaker, E.D., D. Beckett 1998. Coupling of site-specific DNA binding to protein dimerization in assembly of the biotin repressor-biotin operator complex. Biochemistry 37:3210-3219
- Rodionov, D.A., A.A. Mironov, M.S. Gelfand 2002. Conservation of the biotin regulon and the BirA regulatory signal in Eubacteria and Archaea. Genome Res 12:1507-1516