E. coli Genetic Resources at Yale
CGSC, The Coli Genetic Stock Center

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Site mrdA

• Name: mrdA
• Type: Gene
  Synonyms

  b0635	MG1655 locus tag
  pbpA

  
  
• Mnemonic: murein cluster d
• Left End Point: 14.35
• Right End Point: 14.39
  Products:

  penicillin-binding protein 2

  PBP 2

  
  
• Direction: <
• Priority: 1
• External Database Links:

  Host Site	Page Links
  EcoGene.org	EG10606
  EcoliWiki	mrdA

  
  
• Comment:
  • cell shape.
• References:
  • Spratt, B.G., A. Boyd, N.G. Stoker 1980. Defective and plaque-forming lambda transducing bacteriophage carrying penicillin-binding protein-cell shape genes: genetic and physical mapping and identification of gene products from the lip-dacA-rodA-pbpA-l
  
  
  • Tamaki, S., H. Matsuzawa, M. Matsuhashi 1980. Cluster of mrdA and mrdB genes responsible for the rod shape and mecillinam sensitivity of Escherichia coli. J.Bacteriol. 141:52-57
  
  
  • Stoker, N.G., J.M. Pratt, B.G. Spratt 1983. Identification of the rodA gene product of Escherichia coli. J.Bacteriol. 155:854-859
  
  
  • Stoker, N.G., J.K. Broome-Smith, A. Edelman, B.G. Spratt 1983. Organization and subcloning of the dacA-rodA-pbpA cluster of cell shape genes in Escherichia coli. J.Bacteriol. 155:847-853
  
  
  • Asoh, S., H. Matsuzawa, M. Matsuhashi, T. Ohta 1983. Molecular cloning and characterization of the genes pbpA and rodA responsible for the rod shape of Escherichia coli K-12: analysis of gene expression with transposon Tn5 mutagenesis and protein synth
  
  
  • Bryan, S.K., R.E. Moses 1984. Map location of the pcbA mutation and physiology of the mutant. J.Bacteriol. 158:216-221
  
  
  • Begg, K.J., W.D. Donachie 1985. Cell shape and division in Escherichia coli: experiments with shape and division mutants. J.Bacteriol. 163:615-622
  
  
  • Asoh, S., H. Matsuzawa, F. Ishino, J.L. Strominger, M. Matsuhashi, T. Ohta 1986. Nucleotide sequence of the pbpA gene and characteristics of the deduced amino acid sequence of penicillin-binding protein 2 of Escherichia coli K-12. Eur.J.Biochem. 160:23
  
  
  • Adachi, H., T. Ohta, H. Matsuzawa 1987. A water-soluble form of penicillin-binding protein 2 of Escherichia coli constructed by site-directed mutagenesis. FEBS Lett. 226:150-154
  
  
  • Vinella, D., D. Joseleau-Petit, D. Thevenet, P. Bouloc, R. D'Ari 1993. Penicillin-binding protein 2 inactivation in Escherichia coli results in cell division inhibition, which is relieved by FtsZ overexpression. J.Bacteriol. 175:6704-6710
  
  
  • de Pedro, M.A., W.D. Donachie, J.V. Holtje, H. Schwarz 2001. Constitutive septal murein synthesis in Escherichia coli with impaired activity of the morphogenetic proteins RodA and penicillin-binding protein 2. J.Bacteriol. 183:4115-4126