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Site exbD

• Name: exbD
• Type: Gene
  Synonyms

  b3005	MG1655 locus tag

  
  
• Mnemonic: export
• Left End Point: 67.87
• Right End Point: 67.88
  Products:

  membrane protein required for TonB-dependent energy transduction and TonB stability

  TonB-ExbB-ExbD cytoplasmic membrane-anchored complex component

  
  
• Direction: <
• Properties:

  Property	Comment
  encodes membrane protein	TonB-ExbB-ExbD complex transfers energy to open channels in OMP receptors; couples action of OM tranporters FhuA and BtuB across cytoplasmic membr.

  
  
• Priority: 0
  1 Alleles of This Gene

  exbD778(del)::kan

  
  
• External Database Links:

  Host Site	Page Links
  EcoGene.org	EG10272
  EcoliWiki	exbD

  
  
• Comment:
  • strong homology to TolR (TonB-ExbB-ExbD homol.to TolA-TolQ-TolR)
• References:
  • Eick-Helmerich, K., V. Braun 1989. Import of biopolymers into Escherichia coli: nucleotide sequences of the exbB and exbD genes are homologous to those of the tolQ and tolR genes, respectively. J.Bacteriol. 171:5117-5126
  
  
  • Fischer, E., K. Gunter, V. Braun 1989. Involvement of ExbB and TonB in transport across the outer membrane of Escherichia coli: phenotypic complementation of exb mutants by overexpressed tonB and physical stabilization of TonB by ExbB. J.Bacteriol. 171
  
  
  • Braun, V., C. Herrmann 1993. Evolutionary relationship of uptake systems for biopolymers in Escherichia coli: cross-complementation between the TonB-ExbB-ExbD and the TolA-TolQ-TolR proteins. Mol.Microbiol. 8:261-268
  
  
  • Hennessey, E.S., J.K. Broome-Smith 1994. Two related bacterial membrane proteins, ExbD and TolR, have opposite transmembrane charge dipolarity. [Letter]. Mol.Microbiol. 11:417
  
  
  • Killmann, H., V. Braun 1994. Energy-dependent receptor activities of Escherichia coli K-12: mutated TonB proteins alter FhuA receptor activities to phages T5, T1, phi80 and to colicin M. FEMS Microbiol.Lett. 119:71-76
  
  
  • Ahmer, B.M., M.G. Thomas, R. Larsen, K. Postle 1995. Characterization of the exbBD operon of Escherichia coli and the role of ExbB and ExbD in TonB function and stability. J.Bacteriol. 177:4742-4747